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Guy's and St Thomas' NHS Foundation Trust
About
Contact
- Address
- Trust Offices
- St Thomas' Street
- London
- SE1 9RT
- Contact Number
- 020 7188 7188
Clinical Informatician (Senior Cancer RWD Analyst)
Accepting applications until: 21-Jul-2026 23:59
Vacancy status: Open
Accepting applications until: 21-Jul-2026 23:59
Key details
Location
- Site
- London Institute for Healthcare Engineering
- Town
- London
- Postcode
- SE1 7AR
- Major / Minor Region
- London
Contract type & working pattern
- Contract
- 24 months (Fixed term until June 2028)
- Hours
- Full time - 37.5 hours per week
Salary
- Salary
- £66,274 - £73,496 per annum
- Salary period
- Yearly
- Grade
- (NHS AfC: Band 8a)
Specialty
- Main area
- Real-World Data (Analytics / Engineering)
Guy’s and St Thomas’ is among the UK’s busiest and most successful NHS foundation trusts. We provide a full range of hospital and community services for people in south London and as well as specialist care for patients from further afield including cancer, renal, orthopaedic, respiratory and cardiovascular services.
Guy’s is home to the largest dental school in Europe and a £160 million Cancer Centre opened in 2016. As part of our commitment to provide care closer to home, in 2017 we also opened a cancer centre and a kidney treatment centre at Queen Mary’s Hospital in Sidcup. St Thomas’ has one of the largest critical care units in the UK and one of the busiest emergency departments in London. It is also home to Evelina London Children’s Hospital.
Evelina London cares for local children in Lambeth and Southwark and provides specialist services across south east England including cardiac, renal and critical care services. We lead a number of specialist service networks aiming to ensure children are treated locally where possible, but have access to specialist expertise when they need it. Our community services include health visiting, school nursing and support for families of children with long-term conditions.
Our adult community services teams deliver care at the heart of the local communities we serve, working in partnership with GPs, local authorities and other healthcare and voluntary sector organisations. Working with our partners in Lambeth and Southwark, we are focusing on new ways of working to improve care for local patients.
In February 2021 the Royal Brompton and Harefield joined Guy’s and St Thomas’ NHS Foundation Trust, bringing together world-leading expertise in the care and research of heart and lung disease. Our merger provides a once in a generation opportunity to build a lasting, world-renowned heart and lung centre, providing the highest quality care for patients and conducting world-leading research.
We have a reputation for clinical excellence and high quality teaching and research. We are part of King’s Health Partners, one of eight accredited UK academic health sciences centres. In partnership with King’s College London we have dedicated clinical research facilities including an MHRA accredited Phase I clinical trials unit.
Patients are at the heart of everything we do and we pride ourselves on ensuring the best possible patient experience as well as safe, high quality care. We are proud to have one of the lowest mortality rates in the NHS. Following a comprehensive Care Quality Commission (CQC) inspection in 2019 we maintained our overall rating of ‘good’. Our adult community services achieved a rating of ‘outstanding’.
The commitment of our 23,500 staff is key to our success. We are one of the largest local employers and we aim to develop and support all our staff so they are able to deliver high quality, safe and efficient care. The 2019 NHS staff survey results show that we have one of the most engaged and motivated workforces in the NHS. We know this has a positive impact on the care provided to our patients.
We have one of the most ambitious capital investment programmes anywhere in the NHS.
Job overview
This is an exciting opportunity to take a key role in the AI Centre for Value-Based Healthcare, working with the Guy’s Cancer Real-World Evidence (RWE) team.
The Clinical Informatician (Senior Cancer RWD Analyst) bridges RWD and RWE, with a focus on thoracic cancers. The post-holder will curate and develop regulatory-grade, deep cancer data assets, ensuring that outputs are clinically meaningful, aligned with research and commercial needs, and grounded in real-world cancer care delivery.
Essential Criteria:
- Clinical background with understanding of oncology domain
- Expertise in clinical data and informatics, including source systems and clinical and oncology-specific vocabularies
- Expertise in SQL and Python (+/- R) to engineer and analyse datasets, validate cohort definitions, and generate insights and visualisations
- Understanding of cancer clinical research, pharma study / clinical trials, and regulatory requirements for RWD/RWE in oncology
- Excellent stakeholder engagement skills, with the ability to translate between engineering, clinical, and scientific audiences
- Excellent project management skills
Desirable Criteria:
- Experience overseeing clinical validation of NLP-derived features extracted from unstructured medical records
- Track record of high-impact research output and/or commercial partnership delivery in RWE
- Experience building or working with solutions on cloud data platforms (e.g. Snowflake)
Advert
Main duties of the job
- Curate and develop regulatory-grade, deep cancer data assets, focused initially on thoracic malignancies, by defining and validating cohort logic, clinical variables, and derived endpoints.
- Oversee clinical validation of features extracted from unstructured records (clinic letters, radiology, pathology, MDT) and feed back into pipeline improvement.
- Act as the clinical-informatics bridge between AI Centre data engineers and the Guy’s Cancer RWE team, translating between clinical, scientific, and engineering audiences.
- Take the analytical lead on highly complex cancer data, devising methods, setting data-quality KPIs, and making evidence-based recommendations to stakeholders.
- Engage and influence clinical, academic, and commercial partners, and contribute to research outputs and longer-term strategic partnerships.
- Lead and mentor within matrixed project teams, supporting capability-building and the effective use of project resources.
Working for our organisation
AI Centre for Value-Based Healthcare
The AI, Data & Digital Innovation directorate is made up of data and technology experts - based in GSTT but working closely as a team with KCH and KCL.
The team forms part of the Artificial Intelligence Centre for Value-Based Healthcare - a consortium of NHS, academic, and industry partners from across the UK. This consortium offers expert professional technical delivery across data engineering, data science & AI development, and software engineering. Programmes include region-wide infrastructure delivery of cloud and federated platforms, multi-modal Real-World Data engineering, foundation model development, and development of different Language AI solutions.
London / GSTT Snowflake Platform
A secure data and research cloud platform that provides access to some of the broadest and deepest data in the NHS, including low latency patient-level data flows from primary care, linked to Acute Trust data. The platform also supports data science and deployment of advanced analytics and machine learning solutions, including Language AI for unstructured data extraction.
Detailed job description and main responsibilities
Main Duties and Responsibilities
- Support the development of deep cancer data assets, with a primary focus on thoracic malignancies (NSCLC, SCLC, TET and mesothelioma), with possible subsequent expansion to other tumour types.
- Define and validate cohort logic, clinical and pathological variables, derived endpoints (e.g. real-world progression, response, treatment lines), and data quality rules, in collaboration with engineers and the Guy’s RWE thoracic team.
- Oversee clinical validation of NLP-derived features extracted from unstructured sources (clinic letters, radiology, pathology, MDT documentation), and feed back into model and pipeline improvement.
- Produce supporting documentation around data provenance, derivation logic, and quality, in line with regulatory requirements for RWD/RWE generation.
- Help to create standardised, tested, and fully provenanced cancer datasets to support both research and commercial delivery.
- Enable the thoracic RWE team to deliver international academic collaborations within the RWE international programme, such as IASLC.
- Develop analytic tools, datasets, and insights that support business planning, decision-making, and research prioritisation across the cancer RWD/RWE programme.
- Evaluate and analyse highly complex and sometimes contentious cancer data using tested and credible tools, applying robust problem-solving to identify root causes of data-quality issues and opportunities for improvement.
- Determine and track key performance indicators for the depth, coverage, and quality of cancer data assets, working collaboratively with clinical leads and operational teams.
- Manage analytical projects from inception to completion, working autonomously and demonstrating a leadership style consistent with the Trust values.
Guy’s and St Thomas’ celebrates, respects and values the diversity of its staff and patients. We review our policies, procedures and practices to ensure that all employees, patients and carers are treated equitable according to their needs. We are actively committed to ensuring that no one who applies for a job, works or study’s at the Trust, or accesses our services is discriminated against on the grounds of race, ethnicity, nationality, disability, religion or belief, age, gender identity , gender reassignment, sexual orientation, pregnancy and maternity/paternity, or marital/civil partnership.
Applications are welcomed from applicants with a disability. We can make reasonable adjustments and offer support and advice in a variety of ways throughout the application process. Equality of opportunity is our policy.
As an organisation we are committed to developing our services in ways that best suit the needs of our patients. This means that some staff groups will increasingly be asked to work a more flexible shift pattern so that we can offer services in the evenings or at weekends.
Flexible working
We are committed to supporting all employees to achieve a healthy work life balance and to work in a way that is best for them and our patients. We will consider all requests to work flexibly, taking in to account the individual’s personal circumstances as well the needs of the service. We encourage all prospective applicants to discuss their individual circumstances with the recruiting manager as part of the on-boarding process.
Due to recent changes in the UK immigration rules which affect Skilled Worker Visas, Global Business Mobility, Higher Skill Level and Increased Salary Thresholds, please ensure that you are able to meet the requirements to live and work in the UK before applying. Further information about eligibility is available on the UK Government website.
Your e-mail address is important to us - We communicate to all job applicants via the e-mail address which has been provided on the application form. Please ensure that you check your e-mail on a regular basis.
Please apply for this post by clicking "Apply Online Now."
Person specification
Background
Essential criteria
- Clinical background with an understanding of the oncology domain
- Understanding of cancer clinical research, pharma study / clinical trials, and regulatory requirements for RWD/RWE in oncology
Desirable criteria
- Experience overseeing clinical validation of NLP-derived features extracted from unstructured medical records
- Track record of high-impact research output and/or commercial partnership delivery in RWE
Technical
Essential criteria
- Expertise in clinical data and informatics, including understanding of source systems and clinical and oncology-specific vocabularies
- Expertise in SQL and Python (+/- R) sufficient to engineer and analyse datasets, validate cohort definitions, and generate insights and visualisations
Desirable criteria
- Experience building or working with solutions on cloud data platforms (e.g. Snowflake)
General
Essential criteria
- Excellent stakeholder engagement skills, with the ability to translate between engineering, clinical, and scientific audiences
- Excellent project management skills
Further details / informal visits contact
- Name
- Dr. Joe Zhang
- Job title
- Chief Technology Officer
- Email address
- [email protected]
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